Levomepromazine maleate  (Synonyms: Methotrimeprazine maleate)

Levomepromazine maleate (Methotrimeprazine maleate) is an orally active antipsychotic compound and Ca²⁺ release inducer. Levomepromazine maleate inhibits SERCA pump and induces an increase in cytoplasmic Ca²⁺ levels. Levomepromazine maleate has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine maleate can induce adaptive ER stress and autophagy. In addition, Levomepromazine maleate has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine maleate can be used in the study psychiatric disorders and relieving nausea and vomiting^[1][2][3].

444.54

C₂₃H₂₈N₂O₅S

7104-38-3

CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gál G T, et al. Crystal structure of levomepromazine maleate[J]. Acta Crystallographica Section E: Crystallographic Communications, 2016, 72(5): 612-615.  [Content Brief]

  [2]. Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16(1):185-217.  [Content Brief]

  [3]. Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55(5):437-41.  [Content Brief]