Levomepromazine maleate  (Synonyms: Methotrimeprazine maleate)

Levomepromazine maleate (Methotrimeprazine maleate) is an N-substituted phenylthiazine antipsychotic sedative that blocks multiple receptors. Levomepromazine maleate is a potent inhibitor of CYP2D6 and is useful in the study of schizophreni^[1][2].

444.54

C₂₃H₂₈N₂O₅S

7104-38-3

CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gál G T, et al. Crystal structure of levomepromazine maleate[J]. Acta Crystallographica Section E: Crystallographic Communications, 2016, 72(5): 612-615.  [Content Brief]

  [2]. Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16(1):185-217.  [Content Brief]

  [3]. Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55(5):437-41.  [Content Brief]

  [4]. Gram LF, et al. Citalopram: interaction studies with levomepromazine, imipramine, and lithium. Ther Drug Monit. 1993 Feb;15(1):18-24.  [Content Brief]