2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. Lewis y tetrasaccharide

Lewis y tetrasaccharide  (Synonyms: Lewis y)

Cat. No.: HY-N10535 Purity: 99.64%
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Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis.

For research use only. We do not sell to patients.

Lewis y tetrasaccharide Chemical Structure

Lewis y tetrasaccharide Chemical Structure

CAS No. : 82993-43-9

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Based on 1 publication(s) in Google Scholar

Lewis y tetrasaccharide Related Antibodies

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Description

Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].

In Vitro

Lewis Y tetrasaccharide activates FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression to enhance cell adhesion mediated drug resistance (CAM-DR) in ovarian cancer cells[1].
Lewis Y tetrasaccharide results in integrin α5β1 level increase in ovarian carcinoma-derived cells exhibiting enhanced expression of LeY (RMG-1-hFUT)[2].
Lewis Y tetrasaccharide enhances the adhesive and spreading potentials mediated by the integrin-fibronectin interaction of ovarian carcinoma RMG-1 cells[2].
Anti-LeY antibodies (10 μg/mL; 37 ℃; 24 h) significantly inhibits the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lewis y tetrasaccharide Related Antibodies
Molecular Weight

675.63

Formula

C26H45NO19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]([C@@H]([C@@H]([C@@H](O1)C)O)O)[C@@H]1O[C@H]([C@H](C=O)NC(C)=O)[C@@H]([C@H](O)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O[C@H]3[C@H]([C@@H]([C@@H]([C@@H](O3)C)O)O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (185.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4801 mL 7.4005 mL 14.8010 mL
5 mM 0.2960 mL 1.4801 mL 2.9602 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4801 mL 7.4005 mL 14.8010 mL 37.0025 mL
5 mM 0.2960 mL 1.4801 mL 2.9602 mL 7.4005 mL
10 mM 0.1480 mL 0.7401 mL 1.4801 mL 3.7003 mL
15 mM 0.0987 mL 0.4934 mL 0.9867 mL 2.4668 mL
20 mM 0.0740 mL 0.3700 mL 0.7401 mL 1.8501 mL
25 mM 0.0592 mL 0.2960 mL 0.5920 mL 1.4801 mL
30 mM 0.0493 mL 0.2467 mL 0.4934 mL 1.2334 mL
40 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9251 mL
50 mM 0.0296 mL 0.1480 mL 0.2960 mL 0.7401 mL
60 mM 0.0247 mL 0.1233 mL 0.2467 mL 0.6167 mL
80 mM 0.0185 mL 0.0925 mL 0.1850 mL 0.4625 mL
100 mM 0.0148 mL 0.0740 mL 0.1480 mL 0.3700 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lewis y tetrasaccharide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lewis y tetrasaccharide82993-43-9Lewis yFAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasemalignantovarian carcinomasmetastasispoor prognosistetrasaccharide derivativeLewis X trisaccharideInhibitorinhibitorinhibit

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