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Lewis X trisaccharide  (Synonyms: Lewis X)

Cat. No.: HY-N10534 Purity: ≥98.0%
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Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis.

For research use only. We do not sell to patients.

Lewis X trisaccharide Chemical Structure

Lewis X trisaccharide Chemical Structure

CAS No. : 71208-06-5

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Based on 1 publication(s) in Google Scholar

Lewis X trisaccharide Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis[1][2][3].

IC50 & Target

Schistosome

 

In Vitro

Lewis X trisaccharide-BSA (25 μg/mL; 30 min; before LPS stimulation of 10 ng/mL for 4 h) IL-12p40 and suppresses IL-12p70 protein expression induced by Lipopolysaccharide (LPS, HY-D1056)[1].
Lewis X trisaccharide (2 μM; 30 min; before LPS stimulation of 10 ng/mL for 2 h) decreases nuclear NF-κB concentration in mice bone marrow derived dendritic cells (BDDCs)[1].
Lewis X trisaccharide-BSA (25 μg/mL; 48 h) or Lewis X trisaccharide (5 μg/mL; 48 h) plus ovalbumin (OVA, 25 μg/mL) increases cytokines (IL-4, IL-13, and INF-γ) level in mice splenocytes[1].
Lewis X trisaccharide-containing glycoconjugates stimulates B cells to proliferate and to produce factors that down-regulates the TH1 immune response and up-regulates the TH2 immune response[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lewis X trisaccharide Related Antibodies
In Vivo

Lewis X trisaccharide ( 5 μg, combinded with 50 μg ovalbumin; s.c.; once a week for 2 weeks) regulates IgE/TH2 responses, and selectively increases the IgE and IgG1 responses in C3H mice, independent of the LPS-TLR4 signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (BALB/c, IL-12 deficient on a BALB/c background, TLR4-defective C3H/hej, or TLR4-wild type C3H/HeOuj mice) (6-8 weeks old)[1]
Dosage: 5 μg, combinded with 50 μg ovalbumin
Administration: Subcutaneous injection; once a week for 2 weeks
Result: In C3H mice, coupled with BSA (LeX-BSA) and elicited higher levels of specific IgE and IgG1, but not IgG2a, which were associated with increased levels of splenic TH2 cytokines when compared with those seen in BSA-sensitized mice.
In BALB/c mice, induced by ovalbumin, significantly increased levels of specific IgE, resulted IgG2a antibodies concomitant with reduced levels of serum IL-12p70.
In IL-12-deficient BALB/c mice, attenuated the downward trend of the above indicators.
Molecular Weight

529.49

Formula

C20H35NO15
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@H]1O[C@H]([C@H](O)CO)[C@@H]([C@H](C=O)NC(C)=O)O[C@H]2[C@H]([C@@H]([C@@H]([C@@H](O2)C)O)O)O
Structure Classification
Initial Source

human
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (188.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8886 mL 9.4430 mL 18.8861 mL
5 mM 0.3777 mL 1.8886 mL 3.7772 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8886 mL 9.4430 mL 18.8861 mL 47.2152 mL
5 mM 0.3777 mL 1.8886 mL 3.7772 mL 9.4430 mL
10 mM 0.1889 mL 0.9443 mL 1.8886 mL 4.7215 mL
15 mM 0.1259 mL 0.6295 mL 1.2591 mL 3.1477 mL
20 mM 0.0944 mL 0.4722 mL 0.9443 mL 2.3608 mL
25 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8886 mL
30 mM 0.0630 mL 0.3148 mL 0.6295 mL 1.5738 mL
40 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1804 mL
50 mM 0.0378 mL 0.1889 mL 0.3777 mL 0.9443 mL
60 mM 0.0315 mL 0.1574 mL 0.3148 mL 0.7869 mL
80 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL
100 mM 0.0189 mL 0.0944 mL 0.1889 mL 0.4722 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lewis X trisaccharide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lewis X trisaccharide71208-06-5Lewis XParasitegangliosideSialyl-Lewis-X tetrasaccharideSLexcell-cell adhesiontumor markerimmunology researchschistosomiasisparasitic diseaseP-selectindendritic cellsC-type lectin receptorInhibitorinhibitorinhibit

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