2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Lisavanbulin dihydrochloride

Lisavanbulin dihydrochloride  (Synonyms: BAL-101553 dihydrochloride)

Cat. No.: HY-19916A Purity: 99.74%
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Lisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin dihydrochloride exhibits antitumor activity, especially in tumors that express high levels of end-binding protein 1.

For research use only. We do not sell to patients.

Lisavanbulin dihydrochloride Chemical Structure

Lisavanbulin dihydrochloride Chemical Structure

CAS No. : 1387574-54-0

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5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 500 In-stock
50 mg USD 800 In-stock
100 mg USD 1280 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Lisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin dihydrochloride exhibits antitumor activity, especially in tumors that express high levels of end-binding protein 1[1].

Molecular Weight

588.49

Formula

C26H31Cl2N9O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(C(CN2C3=CC=CC=C3N=C2C4=NON=C4NCCC#N)=O)C=C1)[C@@H](N)CCCCN.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (212.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6993 mL 8.4963 mL 16.9926 mL
5 mM 0.3399 mL 1.6993 mL 3.3985 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6993 mL 8.4963 mL 16.9926 mL 42.4816 mL
5 mM 0.3399 mL 1.6993 mL 3.3985 mL 8.4963 mL
10 mM 0.1699 mL 0.8496 mL 1.6993 mL 4.2482 mL
15 mM 0.1133 mL 0.5664 mL 1.1328 mL 2.8321 mL
20 mM 0.0850 mL 0.4248 mL 0.8496 mL 2.1241 mL
25 mM 0.0680 mL 0.3399 mL 0.6797 mL 1.6993 mL
30 mM 0.0566 mL 0.2832 mL 0.5664 mL 1.4161 mL
40 mM 0.0425 mL 0.2124 mL 0.4248 mL 1.0620 mL
50 mM 0.0340 mL 0.1699 mL 0.3399 mL 0.8496 mL
60 mM 0.0283 mL 0.1416 mL 0.2832 mL 0.7080 mL
80 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.5310 mL
100 mM 0.0170 mL 0.0850 mL 0.1699 mL 0.4248 mL
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Lisavanbulin dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lisavanbulin1387574-54-0BAL-101553BAL101553BAL 101553Microtubule/Tubulinsolid tumorglioblastomaDLBCLdiffuse large B cell lymphomaU2932Inhibitorinhibitorinhibit

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