Lithocholic acid 3-sulfate disodium (Synonyms: Sulfolithocholic acid disodium)

Cat. No.: HY-113238A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lithocholic acid 3-sulfate disodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

Lithocholic acid 3-sulfate disodium Chemical Structure

CAS No. : 64936-81-8

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Other Forms of Lithocholic acid 3-sulfate disodium:

Lithocholic acid 3-sulfate-d₄ disodium Get quote
Sulfolithocholic acid Get quote

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Biological Activity
Purity & Documentation
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Description

Lithocholic acid 3-sulfate disodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	> 100 μM Compound: 13, LCA-S	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	[PMID: 18307294]
HEK-293T	EC₅₀	> 150 μM Compound: SLCA	Agonist activity at VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay Agonist activity at VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay	[PMID: 26774929]
HEK-293T	IC₅₀	> 50 μM Compound: SLCA	Antagonist activity against VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of 1,25-dihydroxyvitamin D3-induced SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay Antagonist activity against VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of 1,25-dihydroxyvitamin D3-induced SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay	[PMID: 26774929]

Molecular Weight

500.60

Formula

C₂₄H₃₈Na₂O₆S

CAS No.

64936-81-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCC(O[Na])=O)([H])[C@@](CC[C@]3([H])C[C@@H]4O[S](=O)(O[Na])=O)([H])[C@@]2([H])[C@]3(CC4)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (199.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (49.94 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9976 mL	9.9880 mL	19.9760 mL
5 mM	0.3995 mL	1.9976 mL	3.9952 mL
10 mM	0.1998 mL	0.9988 mL	1.9976 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (243 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.9976 mL	9.9880 mL	19.9760 mL	49.9401 mL
	5 mM	0.3995 mL	1.9976 mL	3.9952 mL	9.9880 mL
	10 mM	0.1998 mL	0.9988 mL	1.9976 mL	4.9940 mL
	15 mM	0.1332 mL	0.6659 mL	1.3317 mL	3.3293 mL
	20 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4970 mL
	25 mM	0.0799 mL	0.3995 mL	0.7990 mL	1.9976 mL
	30 mM	0.0666 mL	0.3329 mL	0.6659 mL	1.6647 mL
	40 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2485 mL
DMSO	50 mM	0.0400 mL	0.1998 mL	0.3995 mL	0.9988 mL
	60 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8323 mL
	80 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL
	100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.4994 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Lithocholic acid 3-sulfate disodium Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lithocholic acid 3-sulfate disodium64936-81-8Sulfolithocholic acid disodiumBiochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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