2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Lobradimil

Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors.

For research use only. We do not sell to patients.

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Lobradimil Chemical Structure

Lobradimil Chemical Structure

CAS No. : 159768-75-9

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5 mg USD 1350 In-stock
10 mg USD 2160 In-stock
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Based on 1 publication(s) in Google Scholar

Lobradimil Related Antibodies

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

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Description

Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors[1].

IC50 & Target[1]

Bradykinin B2 Receptor (B2R)

0.54 nM (Ki)

In Vitro

Lobradimil induces an increase in intracellular free calcium levels in RBME cells[3].
Lobradimil (0.01-0.5 nM, 15 min) increases the permeability of human brain microvascular endothelial cell (HMBEC) monolayers1[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lobradimil Related Antibodies
In Vivo

Lobradimil (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) increases brain tumor permeability and shows hypotensive effects in RG2 glioma cells-implanted rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: RG2 glioma cells-implanted rats[2]
Dosage: 1.5-18 μg/kg
Administration: i.v. infusion, 0.05 mL/min for 15min
Result: Increased Carboplatin (HY-17393) uptake (up to 80%) into brain tumors in a dose-dependent manner.
Clinical Trial
Molecular Weight

1098.28

Formula

C49H75N15O12S
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (45.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9105 mL 4.5526 mL 9.1051 mL
5 mM 0.1821 mL 0.9105 mL 1.8210 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9105 mL 4.5526 mL 9.1051 mL 22.7629 mL
5 mM 0.1821 mL 0.9105 mL 1.8210 mL 4.5526 mL
10 mM 0.0911 mL 0.4553 mL 0.9105 mL 2.2763 mL
15 mM 0.0607 mL 0.3035 mL 0.6070 mL 1.5175 mL
20 mM 0.0455 mL 0.2276 mL 0.4553 mL 1.1381 mL
25 mM 0.0364 mL 0.1821 mL 0.3642 mL 0.9105 mL
30 mM 0.0304 mL 0.1518 mL 0.3035 mL 0.7588 mL
40 mM 0.0228 mL 0.1138 mL 0.2276 mL 0.5691 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lobradimil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lobradimil159768-75-9RMP 7RMP7RMP-7Bradykinin ReceptorBrain tumorRG2 glioma cellHMBECBBBRBME cellInhibitorinhibitorinhibit

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