2. Metabolic Enzyme/Protease
  3. LDLR
  4. LY 295427

LY 295427  (Synonyms: Agisterol)

Cat. No.: HY-125544 Purity: ≥98.0%
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LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research.

For research use only. We do not sell to patients.

LY 295427 Chemical Structure

LY 295427 Chemical Structure

CAS No. : 152755-31-2

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5 mg USD 440 In-stock
10 mg USD 700 In-stock
25 mg USD 1400 In-stock
50 mg USD 2250 In-stock
100 mg USD 3380 In-stock
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Based on 1 publication(s) in Google Scholar

LY 295427 Related Antibodies

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Description

LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3].

In Vitro

LY 295427 time-dependently increases the uptake of 25-OH chol in Chinese hamster ovary (CHO) cells[1].
LY 295427 (2.9 μM) increases 30% LDL receptor promoter activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY 295427 Related Antibodies
In Vivo

LY 295427 dose-dependently decreases cholesterol by derepressing LDL-R transcription in cholesterol-coconut oil-fed hamsters with a ED50 value of 40 mg/kg/day[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

428.73

Formula

C30H52O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(CCC[C@H]([C@H]1CC[C@]2([C@@]3(CC[C@]4([C@@H]([C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)CC=C)[H])[H])[H])C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 15.91 mg/mL (37.11 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3325 mL 11.6624 mL 23.3247 mL
5 mM 0.4665 mL 2.3325 mL 4.6649 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.3325 mL 11.6624 mL 23.3247 mL 58.3118 mL
5 mM 0.4665 mL 2.3325 mL 4.6649 mL 11.6624 mL
10 mM 0.2332 mL 1.1662 mL 2.3325 mL 5.8312 mL
15 mM 0.1555 mL 0.7775 mL 1.5550 mL 3.8875 mL
20 mM 0.1166 mL 0.5831 mL 1.1662 mL 2.9156 mL
25 mM 0.0933 mL 0.4665 mL 0.9330 mL 2.3325 mL
30 mM 0.0777 mL 0.3887 mL 0.7775 mL 1.9437 mL
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LY 295427 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 295427152755-31-2AgisterolLY295427LY-295427LDLRLow-density lipoprotein receptorhypocholesterolemic agenthypercholesterolemiapromoterCHOInhibitorinhibitorinhibit

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