2. TGF-beta/Smad
  3. TGF-β Receptor
  4. M4K2163 dihydrochloride

M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG).

For research use only. We do not sell to patients.

M4K2163 dihydrochloride Chemical Structure

M4K2163 dihydrochloride Chemical Structure

CAS No. : 2863635-04-3

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M4K2163 dihydrochloride Related Antibodies

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG)[1][2].

Molecular Weight

480.40

Formula

C24H28Cl2FN3O2
CAS No.
SMILES

FC1=C(C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC)OC.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M4K2163 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K21632863635-04-3TGF-β ReceptorTransforming growth factor beta receptorsDIPGblood-brain barrierALK2 inhibitorpermeableInhibitorinhibitorinhibit

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