2. Anti-infection
  3. Bacterial
  4. MA220607

MA220607 is an antibacterial agent with low hemolytic toxicity and a dual-target mechanism of action (MOA). MA220607 promotes FtsZ protein polymerization, also increases the permeability of bacterial membranes and inhibits biofilm formation. The resistance rate of MA220607 is low, and the MICs against Gram-positive bacteria and Gram-negative bacteria are Table 0.062-2 μg/mL and 0.5-4 μg/mL, respectively).

For research use only. We do not sell to patients.

MA220607 Chemical Structure

MA220607 Chemical Structure

CAS No. : 2922826-56-8

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5 mg USD 225 In-stock
10 mg USD 360 In-stock
25 mg USD 720 In-stock
50 mg USD 1150 In-stock
100 mg USD 1850 In-stock
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MA220607 Related Antibodies

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Description

MA220607 is an antibacterial agent with low hemolytic toxicity and a dual-target mechanism of action (MOA). MA220607 promotes FtsZ protein polymerization, also increases the permeability of bacterial membranes and inhibits biofilm formation. The resistance rate of MA220607 is low, and the MICs against Gram-positive bacteria and Gram-negative bacteria are Table 0.062-2 μg/mL and 0.5-4 μg/mL, respectively)[1].

IC50 & Target

FtsZ[1]
Molecular Weight

587.58

Formula

C34H38IN
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[N+]1=CC(C2=CC=CC=C2)=C(/C=C/C3=CC=C(C(C)(C)C)C=C3)C=C1C4=CC=C(C(C)(C)C)C=C4.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (198.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7019 mL 8.5095 mL 17.0190 mL
5 mM 0.3404 mL 1.7019 mL 3.4038 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7019 mL 8.5095 mL 17.0190 mL 42.5474 mL
5 mM 0.3404 mL 1.7019 mL 3.4038 mL 8.5095 mL
10 mM 0.1702 mL 0.8509 mL 1.7019 mL 4.2547 mL
15 mM 0.1135 mL 0.5673 mL 1.1346 mL 2.8365 mL
20 mM 0.0851 mL 0.4255 mL 0.8509 mL 2.1274 mL
25 mM 0.0681 mL 0.3404 mL 0.6808 mL 1.7019 mL
30 mM 0.0567 mL 0.2836 mL 0.5673 mL 1.4182 mL
40 mM 0.0425 mL 0.2127 mL 0.4255 mL 1.0637 mL
50 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8509 mL
60 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7091 mL
80 mM 0.0213 mL 0.1064 mL 0.2127 mL 0.5318 mL
100 mM 0.0170 mL 0.0851 mL 0.1702 mL 0.4255 mL
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MA220607 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MA2206072922826-56-8MA 220607MA-220607BacterialAntibacterial agentsBacterial membraneDual-targeting mechanismFtsZ proteinInhibitorinhibitorinhibit

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