2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Makaluvamine A

Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells.

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Makaluvamine A Chemical Structure

Makaluvamine A Chemical Structure

CAS No. : 146555-78-4

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Makaluvamine A Related Antibodies

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Description

Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells[1].

Cellular Effect
Cell Line Type Value Description References
NIH3T3 IC50
5 μM
Compound: 9
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
[PMID: 12027767]
Molecular Weight

201.22

Formula

C11H11N3O
CAS No.
SMILES

O=C1C2=C3C(CCN=C3C=C1N)=CN2C
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Purity & Documentation
References
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Makaluvamine A Related Classifications

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Keywords:

Makaluvamine A146555-78-4TopoisomeraseInhibitorinhibitorinhibit

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