2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. Mal-PEG8-Val-Ala-PAB-Exatecan

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research.

For research use only. We do not sell to patients.

Mal-PEG8-Val-Ala-PAB-Exatecan Chemical Structure

Mal-PEG8-Val-Ala-PAB-Exatecan Chemical Structure

CAS No. : 2679821-39-5

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1 mg USD 224 In-stock
5 mg USD 560 In-stock
10 mg USD 900 In-stock
25 mg USD 1685 In-stock
50 mg USD 2700 In-stock
100 mg USD 4000 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Mal-PEG8-Val-Ala-PAB-Exatecan Related Antibodies

Top Publications Citing Use of Products

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1329.42

Formula

C66H85FN8O20
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O.[7]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (75.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7522 mL 3.7610 mL 7.5221 mL
5 mM 0.1504 mL 0.7522 mL 1.5044 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.48%

COA (249 KB) HNMR (250 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7522 mL 3.7610 mL 7.5221 mL 18.8052 mL
5 mM 0.1504 mL 0.7522 mL 1.5044 mL 3.7610 mL
10 mM 0.0752 mL 0.3761 mL 0.7522 mL 1.8805 mL
15 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.2537 mL
20 mM 0.0376 mL 0.1881 mL 0.3761 mL 0.9403 mL
25 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.7522 mL
30 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6268 mL
40 mM 0.0188 mL 0.0940 mL 0.1881 mL 0.4701 mL
50 mM 0.0150 mL 0.0752 mL 0.1504 mL 0.3761 mL
60 mM 0.0125 mL 0.0627 mL 0.1254 mL 0.3134 mL
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Mal-PEG8-Val-Ala-PAB-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG8-Val-Ala-PAB-Exatecan2679821-39-5Drug-Linker Conjugates for ADCTopoisomeraseNectin-4anticancerInhibitorinhibitorinhibit

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