2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. Mal-VC-PAB-DMEA-PNU-159682

Mal-VC-PAB-DMEA-PNU-159682 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-topoisomerase II agent, PNU-159682, linked via the lysosomally cleavable dipeptide, Mc-VC-PAB. Mal-VC-PAB-DMEA-PNU-159682 can be used in the synthesis of Anti-CD22-NMS249 (HY-164761).

For research use only. We do not sell to patients.

Mal-VC-PAB-DMEA-PNU-159682 Chemical Structure

Mal-VC-PAB-DMEA-PNU-159682 Chemical Structure

CAS No. : 1178887-17-6

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Mal-VC-PAB-DMEA-PNU-159682 Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Mal-VC-PAB-DMEA-PNU-159682 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-topoisomerase II agent, PNU-159682, linked via the lysosomally cleavable dipeptide, Mc-VC-PAB. Mal-VC-PAB-DMEA-PNU-159682 can be used in the synthesis of Anti-CD22-NMS249 (HY-164761)[1].

Molecular Weight

1354.41

Formula

C66H83N9O22
CAS No.
SMILES

OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@]6([H])N7[C@]([C@H](OCC7)OC)([H])O[C@]6([H])[C@@H](O5)C)=C1C[C@](O)(C4)C(COC(N(C)CCN(C)C(OCC8=CC=C(C=C8)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mal-VC-PAB-DMEA-PNU-159682 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-VC-PAB-DMEA-PNU-1596821178887-17-6SET0568SET 0568SET-0568Drug-Linker Conjugates for ADCTopoisomeraseInhibitorinhibitorinhibit

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