2. PROTAC
  3. PROTAC Linkers
  4. Maleimide-C10-NHS ester

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Maleimide-C10-NHS ester Chemical Structure

Maleimide-C10-NHS ester Chemical Structure

CAS No. : 87981-04-2

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Based on 1 publication(s) in Google Scholar

Maleimide-C10-NHS ester Related Antibodies

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Description

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Maleimide-C10-NHS ester Related Antibodies
Molecular Weight

378.42

Formula

C19H26N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(CCC1=O)=O)CCCCCCCCCCN2C(C=CC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Maleimide-C10-NHS ester Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maleimide-C10-NHS ester87981-04-2PROTAC LinkersInhibitorinhibitorinhibit

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