2. Metabolic Enzyme/Protease
  3. FBPase
  4. Managlinat dialanetil

Managlinat dialanetil  (Synonyms: MB06322; CS-917)

Cat. No.: HY-14955 Purity: 98.13%
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Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes .

For research use only. We do not sell to patients.

Managlinat dialanetil Chemical Structure

Managlinat dialanetil Chemical Structure

CAS No. : 280782-97-0

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1 mg USD 200 In-stock
5 mg USD 500 In-stock
10 mg USD 800 In-stock
25 mg USD 1440 In-stock
50 mg USD 2160 In-stock
100 mg USD 2960 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes[1] [2].

IC50 & Target

FBPase[1][2]
Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
10 μM
Compound: 2, CS-917
Antidiabetic activity in monkey hepatocytes assessed as inhibition of glucose production after 4 hrs
Antidiabetic activity in monkey hepatocytes assessed as inhibition of glucose production after 4 hrs
[PMID: 20542703]
In Vivo

Managlinat dialanetil dose-dependently inhibits GNG as well as lower basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

500.55

Formula

C21H33N4O6PS
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CC(C)CC(S1)=C(C(O2)=CC=C2[P](N[C@@H](C)C(OCC)=O)(N[C@@H](C)C(OCC)=O)=O)N=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (49.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9978 mL 9.9890 mL 19.9780 mL
5 mM 0.3996 mL 1.9978 mL 3.9956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9978 mL 9.9890 mL 19.9780 mL 49.9451 mL
5 mM 0.3996 mL 1.9978 mL 3.9956 mL 9.9890 mL
10 mM 0.1998 mL 0.9989 mL 1.9978 mL 4.9945 mL
15 mM 0.1332 mL 0.6659 mL 1.3319 mL 3.3297 mL
20 mM 0.0999 mL 0.4995 mL 0.9989 mL 2.4973 mL
25 mM 0.0799 mL 0.3996 mL 0.7991 mL 1.9978 mL
30 mM 0.0666 mL 0.3330 mL 0.6659 mL 1.6648 mL
40 mM 0.0499 mL 0.2497 mL 0.4995 mL 1.2486 mL
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Managlinat dialanetil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Managlinat dialanetil280782-97-0MB06322 CS-917MB 06322MB-06322CS917CS 917CS-917FBPasefructose-1,6-bisphosphataseInhibitorinhibitorinhibit

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