2. Anti-infection NF-κB Apoptosis Metabolic Enzyme/Protease
  3. Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450
  4. Mancozeb

Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.

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Mancozeb Chemical Structure

Mancozeb Chemical Structure

CAS No. : 8018-01-7

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Based on 1 publication(s) in Google Scholar

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Mancozeb Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells[1][2][3][4].

In Vitro

Mancozeb (0.1-500 ppm; 24-48 h) is highly toxic to HepG2 cells, and can affect cell metabolism and induce cell damage[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mancozeb Related Antibodies

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 0.1, 1, 10, 100 and 500 ppm;
1, 10 and 100 ppm
Incubation Time: 24 h;
48 h
Result: Was toxic to cells at all concentrations.
Reduced cell viability (to below 50%) at 24 h, resulted in total cell death with a 48-hour exposure to 100ppm.

Western Blot Analysis[2]

Cell Line: HepG2 cells
Concentration: 0.1, 1, 10 and 100 ppm
Incubation Time: 24 h and 48 h
Result: Reduced the levels of LDH and cytochrome c.
In Vivo

Mancozeb (0-300 mg/kg; Take orally; At 30 days) causes liver injury in mice by activating Keap1/Nrf2 signaling pathway, but was alleviated by Glycyrrhiza polysaccharides[3].
Mancozeb (100 mg/kg; Gavage; 30 days) can cause ovarian injury and apoptosis in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kunming mice aged 6 weeks old[3]
Dosage: 0, 50, 100, 150, 200, 250 and 300 mg/kg
Administration: Oral administration (p.o.); 30 days
Result: Reduced body weight in mice in a concentration-dependent manner.
Significantly reduced the liver organ index of mice at doses of 250 mg/kg and 300 mg/kg.
Reduced the levels of CAT, SOD and ROS in a concentration-dependent manner.
Significantly up-regulated the levels of Keap1 and Nrf2 in the liver.
Animal Model: Kunming mice aged 6 weeks old[4]
Dosage: 100 mg/kg
Administration: Oral gavage (i.g.); 30 days
Result: Reduced body weight in mice.
Destroyed the ovary structure of mice and decreased the levels of follicle stimulating hormone and luteinizing hormone.
Caused mitochondrial oxidative phosphorylation dysfunction and oxidative stress.
Activated the Bax/Bcl-2 pathway and caspase family, thereby inducing apoptosis.
Molecular Weight

661.36

Formula

C8H12Mn2N4S8Zn22-
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

S=C([S-])NCCNC1=[S][Mn]([Mn+])[S-]1.S=C([S-])NCCNC2=[S][Zn]([Zn+])[S-]2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (1.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5120 mL 7.5602 mL 15.1204 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5120 mL 7.5602 mL 15.1204 mL 37.8009 mL
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Mancozeb Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mancozeb8018-01-7FungalKeap1-Nrf2ApoptosisLactate DehydrogenaseCytochrome P450LDHCYPsFungicideOvarian cellsHepG2 cellsLiver injuryInhibitorinhibitorinhibit

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