2. Cytoskeleton Epigenetics TGF-beta/Smad
  3. MARCKS PKC
  4. MANS peptide

MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.

For research use only. We do not sell to patients.

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MANS peptide Chemical Structure

MANS peptide Chemical Structure

CAS No. : 479482-23-0

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MANS peptide Related Antibodies

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Description

MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1].

In Vitro

MANS peptide (0-100 μM, 12-24 h) inhibits migration and invasion of lung cancer cells CL1-0/F3, CL1-5, PC9 and A549 without causing toxicity to normal cells[1].
MANS peptide (0-100 μM, 16 h) inihibits MARCKS phosphorylation and PI3K and AKT phosphorylation, leads to downstream changes in Slug and E-cadherin expression levels, prevents the loss of cell-cell adhesion, alters epithelial-mesenchymal transition (EMT) characteristics of cancer cells, and thus decreases tumor metastasis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MANS peptide Related Antibodies

Cell Viability Assay[1]

Cell Line: CL1-0/F3, CL1-5 and PC9
Concentration: 0-100 μM
Incubation Time: 12-24 h
Result: Inhibited migration.

Western Blot Analysis[1]

Cell Line: CL1-0/F3, CL1-5, PC9 and NHBE
Concentration: 0-100 μM
Incubation Time: 16 h
Result: Upregulated levels of E-cadherin, downregulated levels of Slug.
Suppressed MARCKS phosphorylation and AKT/Slug pathway.
In Vivo

MANS peptide (50 nmol/injection, ip, every 3 days for 6 injection) inhibits tumor metastasis, without affecting tumorigenesis in PC9 xenograft NOD/SCID mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice model[1]
Dosage: 50 nmol/injection
Administration: Ip, every 3 days for 6 times
Result: Suppressed micrometastatic lesions.
Molecular Weight

2498.83

Formula

C111H184N30O35
CAS No.
Sequence

{Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala
Sequence Shortening

{Myristic acid-Gly}-AQFSKTAAKGEAAAERPGEAAVA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MANS peptide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MANS peptide479482-23-0MARCKSPKCMyristoylated alanine-rich C kinase substrateProtein kinase CCL1-0/F3CL1-5PC9A549NOD/SCID miceInhibitorinhibitorinhibit

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