MAO-A/B-IN-3 

MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC₅₀ values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases^[1].

MAO-A/B-IN-3 (Compound 12) exhibites moderate permeability (16.49 nm/s) in vitro Caco2 permeability across the intestinal membrane^[1].
MAO-A/B-IN-3 (Compound 12) displays moderate permeability (103.16 nm/s) to MDCK cells^[1].
MAO-A/B-IN-3 (Compound 12) shows 90.97% plasma protein binding, with a binding rate more than 90% indicating strong binding, indicating its longer half-life and slow excretion profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-A/B-IN-3 (Compound 12) (20 mg/kg; i.p.; 60 min) increases the immobility period of animals and thus emerged as CNS depressants^[1].
MAO-A/B-IN-3 (Compound 12) (30 mg/kg; i.p.; 30min) possesses significant anxiolytic activity and a few compounds displayed superior activity compared to the reference drug diazepam^[1].
MAO-A/B-IN-3 (Compound 12) (30 mg/kg; i.p.; 0.5h and 4h) is non-neurotoxic up to 4 h in male Male albino mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

308.33

C₁₇H₁₆N₄O₂

315210-31-2

O=C(N/N=C(C1=CC=C(O)C=C1)\C)CN(C=N2)C3=C2C=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kumar S, et al. Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-20.  [Content Brief]