2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-30

MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier MAO-B inhibitor with IC50 values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease.

For research use only. We do not sell to patients.

MAO-B-IN-30 Chemical Structure

MAO-B-IN-30 Chemical Structure

CAS No. : 82973-15-7

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Based on 1 publication(s) in Google Scholar

MAO-B-IN-30 Related Antibodies

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  • Purity & Documentation

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Description

MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier MAO-B inhibitor with IC50 values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease[1].

IC50 & Target[1]

MAO-B

0.082 μM (IC50)

MAO-A

19.176 μM (IC50)

In Vitro

MAO-B-IN-30 (compound IS7) (0-100 µM) shows antiproliferative activity with IC50 value of 97.15 µM in SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-30 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited cell growth and non-cytotoxic.
Molecular Weight

344.16

Formula

C15H10BrN3O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(/C1=N\NC(C2=CC=C(Br)C=C2)=O)NC3=C1C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (12.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9056 mL 14.5281 mL 29.0563 mL
5 mM 0.5811 mL 2.9056 mL 5.8113 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9056 mL 14.5281 mL 29.0563 mL 72.6406 mL
5 mM 0.5811 mL 2.9056 mL 5.8113 mL 14.5281 mL
10 mM 0.2906 mL 1.4528 mL 2.9056 mL 7.2641 mL
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MAO-B-IN-30 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-3082973-15-7Monoamine OxidaseMAOSH-SY5Y cellsParkinson's diseaseantiproliferativeanti-inflammatoryInhibitorinhibitorinhibit

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