2. Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt Neuronal Signaling
  3. Toll-like Receptor (TLR) p38 MAPK JNK ERK Cholinesterase (ChE)
  4. MAPK-IN-1

MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research.

For research use only. We do not sell to patients.

MAPK-IN-1 Chemical Structure

MAPK-IN-1 Chemical Structure

CAS No. : 2470587-69-8

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Based on 1 publication(s) in Google Scholar

MAPK-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MAPK-IN-1

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].

IC50 & Target

TLR4

 

In Vitro

MAPK-IN-1 (Compound 2) inhibits NO, IL-1β, IL-6, and TNF-α release in BV-2 cells with IC50 values of 0.49 ± 0.17, 1.34 ± 0.21, 9.17 ± 0.17 and 8.17 ± 0.23 μM, respectively[1].
MAPK-IN-1 downregulates LPS-induced phosphorylation of JNK, ERK, and p38 in MAPK signaling pathway[1].
MAPK-IN-1 inhibits expressions of iNOS, COX-2, and TLR4 in LPS-induced BV-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAPK-IN-1 Related Antibodies
Molecular Weight

310.34

Formula

C19H18O4
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C1CCC(C2=C(C3=C(C(C2=O)=O)[C@@H](C)CO3)C=C4)=C4C1(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (322.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2223 mL 16.1114 mL 32.2227 mL
5 mM 0.6445 mL 3.2223 mL 6.4445 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2223 mL 16.1114 mL 32.2227 mL 80.5568 mL
5 mM 0.6445 mL 3.2223 mL 6.4445 mL 16.1114 mL
10 mM 0.3222 mL 1.6111 mL 3.2223 mL 8.0557 mL
15 mM 0.2148 mL 1.0741 mL 2.1482 mL 5.3705 mL
20 mM 0.1611 mL 0.8056 mL 1.6111 mL 4.0278 mL
25 mM 0.1289 mL 0.6445 mL 1.2889 mL 3.2223 mL
30 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6852 mL
40 mM 0.0806 mL 0.4028 mL 0.8056 mL 2.0139 mL
50 mM 0.0644 mL 0.3222 mL 0.6445 mL 1.6111 mL
60 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
80 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0070 mL
100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.8056 mL
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MAPK-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAPK-IN-12470587-69-8Toll-like Receptor (TLR)p38 MAPKJNKERKCholinesterase (ChE)c-Jun N-terminal kinaseExtracellular signal regulated kinasesBV2neuroinflammatoryp38Alzheimer's diseaseHT22Inhibitorinhibitorinhibit

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