1. Academic Validation
  2. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids

In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids

  • J Nat Prod. 2000 Dec;63(12):1638-40. doi: 10.1021/np000144r.
C W Wright 1 S J Marshall P F Russell M M Anderson J D Phillipson G C Kirby D C Warhurst P L Schiff
Affiliations

Affiliation

  • 1 The School of Pharmacy, University of Bradford, West Yorkshire, BD7 1DP, UK. c.w.wright@bradford.ac.uk
Abstract

Twenty-one Alkaloids have been assessed for activities against Plasmodium falciparum (multidrug- resistant strain K1) in vitro; 18 of these are reported for the first time. Two Protoberberine Alkaloids, dehydrodiscretine and berberine, were found to have antiplasmodial IC(50) values less than 1 M, while seven alkaloids-allocrytopine, columbamine, dehydroocoteine, jatrorrhizine, norcorydine, thalifendine, and ushinsunine-had values between 1 and 10 M. These results are discussed in the context of structure-activity relationships. Compounds were also assessed for antiamoebic and cytotoxic activities, but none was significantly active except for berberine, which was moderately cytotoxic.

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