2. Academic Validation
  3. Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata

Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata

  • J Nat Prod. 2001 Apr;64(4):533-5. doi: 10.1021/np0005210.
N Alam 1,  B H Bae,  J Hong,  C O Lee,  B A Shin,  K S Im,  J H Jung
Affiliations

Affiliation

  • 1 College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
PMID: 11325244 DOI: 10.1021/np0005210
Abstract

A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the Sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of Cholesterol and cytotoxicity against human solid tumor cell lines are reported.

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