2. Academic Validation
  3. Inhibition of cytokine production by hymenialdisine derivatives

Inhibition of cytokine production by hymenialdisine derivatives

  • J Med Chem. 2004 Jul 1;47(14):3700-3. doi: 10.1021/jm040013d.
Vasudha Sharma 1,  Theresa A Lansdell,  Guangyi Jin,  Jetze J Tepe
Affiliations

Affiliation

  • 1 Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
PMID: 15214798 DOI: 10.1021/jm040013d
Abstract

We describe herein the synthesis and biological activity of two indoloazepines that are structurally related to the marine Sponge metabolite hymenialdisine. The natural product hymenialdisine was found to be a potent inhibitor of interleukin-2 (IC(50) = 2.4 microM) and tumor necrosis factor alpha (IC(50) = 1.4 microM) production. One of the hymenialdisine derived indoloazepines was found to also inhibit interleukin-2 (IC(50) = 3.5 microM) and tumor necrosis factor alpha (IC(50) = 8.2 microM) production.

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