2. Academic Validation
  3. Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate

Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate

  • Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):245-56. doi: 10.1016/j.cytogfr.2007.04.004.
Alessandra Micera 1,  Alessandro Lambiase,  Barbara Stampachiacchiere,  Stefano Bonini,  Sergio Bonini,  Francesca Levi-Schaffer
Affiliations

Affiliation

  • 1 Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.
PMID: 17531524 DOI: 10.1016/j.cytogfr.2007.04.004
Abstract

This review deals with the role of nerve growth factor (NGF) in healing process as a result of injury. The role of both TrkA(NGFR) and p75(NTR) specific NGF receptors and their contribution in the complex network of tissue repair process, is discussed and highlighted in view of recent findings. In fact, NGF represents a significant advance in the treatment of etiologically different ulcers (corneal ulcers, pressure ulcers, post-viral infections, chemical burns) and might shorten the recovery process. For these diseases, no specific treatment is actually available. It is reasonable that apart from NGF and/or neurotrophins a different time-course of TrkA(NGRF)/p75(NTR) expression, might regulate the final process. In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions.

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