2. Academic Validation
  3. Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil

Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil

  • J Nat Prod. 2008 Mar;71(3):334-9. doi: 10.1021/np0705256.
Miriam H Kossuga 1,  Andréa M Nascimento,  Juliana Q Reimão,  André G Tempone,  Noemi Nosomi Taniwaki,  Katyuscya Veloso,  Antonio G Ferreira,  Bruno C Cavalcanti,  Claudia Pessoa,  Manoel O Moraes,  Alejandro M S Mayer,  Eduardo Hajdu,  Roberto G S Berlinck
Affiliations

Affiliation

  • 1 Instituto de quimica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Brazil.
PMID: 18177008 DOI: 10.1021/np0705256
Abstract

Investigation of the bioactive crude extract from the Sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from Other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P ( 3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2- 6 were tested for cytotoxicity against four human Cancer cell lines, but displayed only moderate cytotoxic activity.

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