2. Academic Validation
  3. Synthesis and bioevaluation of 22-hydroxyacuminatine analogs

Synthesis and bioevaluation of 22-hydroxyacuminatine analogs

  • Bioorg Med Chem Lett. 2008 Mar 15;18(6):2143-6. doi: 10.1016/j.bmcl.2008.01.082.
François Grillet 1,  Barbora Baumlová,  Grégoire Prévost,  Jean-François Constant,  Sophie Chaumeron,  Dennis C H Bigg,  Andrew E Greene,  Alice Kanazawa
Affiliations

Affiliation

  • 1 Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France.
PMID: 18276141 DOI: 10.1016/j.bmcl.2008.01.082
Abstract

A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on Cancer cell lines and for Topoisomerase I inhibitory activity.

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