2. Academic Validation
  3. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol

Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol

  • Med Clin North Am. 1989 Mar;73(2):437-48. doi: 10.1016/s0025-7125(16)30681-2.
W H Frishman 1,  R C Rapier
Affiliations

Affiliation

  • 1 Albert Einstein College of Medicine, Bronx, New York.
PMID: 2645482 DOI: 10.1016/s0025-7125(16)30681-2
Abstract

Increased levels of Cholesterol, LDL-cholesterol, and VLDL-cholesterol are known risk factors for the development of coronary artery disease. There are multiple drugs that can be used for lowering Cholesterol, including lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting Enzyme step in Cholesterol synthesis in the body. The pharmacology of this novel agent is discussed in this article.

Figures
Products