2. Academic Validation
  3. New 4-methylidene sterols from the marine sponge Theonella swinhoei

New 4-methylidene sterols from the marine sponge Theonella swinhoei

  • Fitoterapia. 2018 Jun;127:279-285. doi: 10.1016/j.fitote.2018.03.006.
Fan Yang 1,  Yan-Yun Li 1,  Jie Tang 1,  Fan Sun 1,  Hou-Wen Lin 2
Affiliations

Affiliations

  • 1 Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
  • 2 Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: franklin67@126.com.
PMID: 29540311 DOI: 10.1016/j.fitote.2018.03.006
Abstract

A series of 4-methylidene sterols including three new compounds 1-3, were isolated from the marine Sponge Theonella swinhoei. The structures of new compounds were determined on the basis of spectroscopic analyses. Compounds 3, 5, and 6 showed cytotoxicities against U937, MCF-7, and PC-9 Cancer cells with IC50 in the range of 1.6-8.8 μM. The new compound 3 exhibited remarkable proapoptotic activity in breast Cancer cells. Mechanically, 3 significantly triggered Reactive Oxygen Species (ROS) accumulation resulting in Apoptosis and DNA damage in breast Cancer cells.

Keywords

4-Methylidene sterol; Antitumor; ROS; Theonella swinhoei.

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