2. Academic Validation
  3. Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma

Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma

  • Biomaterials. 2019 Dec;223:119464. doi: 10.1016/j.biomaterials.2019.119464.
Lijia Luo 1,  Muhammad Zubair Iqbal 2,  Chuang Liu 1,  Jie Xing 2,  Ozioma Udochukwu Akakuru 1,  Qianlan Fang 1,  Zihou Li 2,  Yunlu Dai 3,  Aiguo Li 4,  Yong Guan 5,  Aiguo Wu 6
Affiliations

Affiliations

  • 1 Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
  • 2 Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, PR China.
  • 3 Faculty of Health Sciences, University of Macau, Macau SAR, 999078, PR China.
  • 4 Shanghai Synchrotron Radiation Facility, Chinese Academy of Sciences, Shanghai, 201204, PR China.
  • 5 National Synchrotron Radiation Laboratory in Hefei, University of Science & Technology of China, Hefei, 230026, PR China.
  • 6 Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, PR China. Electronic address: aiguo@nimte.ac.cn.
PMID: 31525691 DOI: 10.1016/j.biomaterials.2019.119464
Abstract

Malignant melanoma, one of the most aggressive types of Cancer easily metastasizes, making it extremely difficult to treat and unresponsive to current therapies. Recent breakthroughs in nanomaterials-based Cancer Immunotherapy have provided potential specific strategy for tumor and metastasis inhibition. With the development of nanotechnology, inorganic nanomaterials have been increasingly studied for their potential Cancer therapeutic and molecular imaging functions. However, only iron-based nanomaterials have been approved by the Food and Drug Administration (FDA) in inorganic nanomedicines. For promising clinical application, a new type of nanocomposite is engineered by combining ultra-small iron oxide nanoparticles (Fe3O4 NPs) and ovalbumin (OVA), denoted as Fe3O4-OVA nanocomposites in this study. Interestingly, this is the first time that Fe3O4 NPs are found as nano-immunopotentiators helping nanocomposites efficiently stimulate dendritic cell-based immunotherapy and potentially-activate macrophages. These nanocomposites efficiently stimulate the maturation level of bone marrow derived dendritic cell (BMDCs) and corresponding activation of T cells and also potentially-activate macrophages. With the help of the Fe3O4 nano-immunopotentiators (Fe3O4 NPs), this therapeutic and prophylactic Fe3O4-OVA vaccine can not only efficiently inhibit the subcutaneous and metastatic B16-OVA tumor growth but also successfully prevent the formation of subcutaneous and metastatic tumor, providing a promising strategy for expanding the clinical use of Fe-based nanomaterials.

Keywords

Cancer immunotherapy; Dendritic cells; Metastasis; Nanomaterials; Prophylactic vaccines.

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