2. Academic Validation
  3. Corilagin suppresses RANKL-induced osteoclastogenesis and inhibits oestrogen deficiency-induced bone loss via the NF-κB and PI3K/AKT signalling pathways

Corilagin suppresses RANKL-induced osteoclastogenesis and inhibits oestrogen deficiency-induced bone loss via the NF-κB and PI3K/AKT signalling pathways

  • J Cell Mol Med. 2020 Sep;24(18):10444-10457. doi: 10.1111/jcmm.15657.
Jinwei Lu 1 2,  Chenyi Ye 1 2,  Yanyong Huang 1 2 3,  Donghui Huang 4,  Lan Tang 1 2,  Weiduo Hou 1 2,  Zhihui Kuang 1 2,  Yazhou Chen 1 2,  Shining Xiao 1 2,  Mumingjiang Yishake 5,  Rongxin He 1 2
Affiliations

Affiliations

  • 1 Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • 2 Orthopedics Research Institute of Zhejiang University, Hangzhou, China.
  • 3 Department of Orthopedic Surgery, The First People's Hospital of Xiaoshan District, Hangzhou, China.
  • 4 Department of Orthopedic Surgery, Hangzhou Third Hospital, Hangzhou, China.
  • 5 Orthopedics Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
PMID: 32681612 DOI: 10.1111/jcmm.15657
Abstract

Over-activated osteoclastogenesis, which is initiated by inflammation, has been implicated in osteoporosis. Corilagin, a natural compound extracted from various medicinal herbaceous Plants, such as Cinnamomum Cassia, has antioxidant and anti-inflammatory activities. We found that Corilagin suppressed osteoclast differentiation in a dose-dependent manner, significantly decreased osteoclast-related gene expression and impaired bone resorption by osteoclasts. Moreover, phosphorylation of members of the nuclear factor-kappaB (NF-κB) and PI3K/Akt signalling pathways was reduced by Corilagin. In a murine model of osteoporosis, Corilagin inhibited osteoclast functions in vivo and restored oestrogen deficiency-induced bone loss. In conclusion, our findings suggested that Corilagin inhibited osteoclastogenesis by down-regulating the NF-κB and PI3K/Akt signalling pathways, thus showing its potential possibility for the treatment of osteoporosis.

Keywords

Corilagin; NF-κB; PI3K/AKT; RANKL; osteoclast.

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