2. Academic Validation
  3. Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway

Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway

  • Sci Rep. 2021 Feb 23;11(1):4391. doi: 10.1038/s41598-021-83924-4.
Chenhao Tong  # 1,  Yali Wang  # 1,  Jiandong Li 1,  Wenda Cen 2,  Weiguang Zhang 3,  Zhiyang Zhu 1,  Jianhua Yu 4 5,  Baochun Lu 6 7
Affiliations

Affiliations

  • 1 Department of Hepatobiliary Surgery, Shaoxing Hospital, Zhejiang University School of Medicine (Shaoxing People's Hospital), No. 568 Zhongxing North Road, Shaoxing, 312000, Zhejiang, China.
  • 2 Shaoxing University School of Medicine, Shaoxing, China.
  • 3 Department of Molecular Medicine and Clinical Laboratory, Shaoxing Second Hospital, Shaoxing, China.
  • 4 Department of Hepatobiliary Surgery, Shaoxing Hospital, Zhejiang University School of Medicine (Shaoxing People's Hospital), No. 568 Zhongxing North Road, Shaoxing, 312000, Zhejiang, China. yujianhua@zju.edu.cn.
  • 5 Shaoxing University School of Medicine, Shaoxing, China. yujianhua@zju.edu.cn.
  • 6 Department of Hepatobiliary Surgery, Shaoxing Hospital, Zhejiang University School of Medicine (Shaoxing People's Hospital), No. 568 Zhongxing North Road, Shaoxing, 312000, Zhejiang, China. sygd_lbc@126.com.
  • 7 Shaoxing University School of Medicine, Shaoxing, China. sygd_lbc@126.com.
  • # Contributed equally.
PMID: 33623100 DOI: 10.1038/s41598-021-83924-4
Abstract

Gallbladder Cancer is the most common malignant tumor of the biliary system and is characterized by difficulty to diagnose in early stages, a high degree of malignancy, and poor prognosis. Finding new drugs may improve the prognosis for this dismal Cancer. Herein, we investigated the potential application of pterostilbene (PTS) against gallbladder Cancer in vivo and in vitro. PTS potently inhibited cell proliferation, migration and invasion of gallbladder Cancer cells. Moreover, PTS also had a function of inducing Apoptosis in vitro. Meanwhile, PTS reversed EMT with a correlated inhibition of PI3K/Akt activation. Tumor xenograft models showed that PTS inhibited tumor growth and had low toxicity in vivo, which were consistent with the in vitro data. These findings indicate that PTS arrests cell growth through inhibition of PI3K/Akt signaling and is a potential drug for the therapy of gallbladder Cancer.

Figures
Products