2. Academic Validation
  3. Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings

Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings

  • Int J Biol Macromol. 2021 Jul 31;183:1145-1154. doi: 10.1016/j.ijbiomac.2021.05.031.
Liuzhu Zhou 1,  Ling Cai 1,  Hongjie Ruan 2,  Li Zhang 1,  Jun Wang 1,  Huijun Jiang 3,  Yuan Wu 4,  Shanwu Feng 2,  Jin Chen 5
Affiliations

Affiliations

  • 1 Center for Global Health, School of Public Health, Nanjing Medical University, 211166 Nanjing, China.
  • 2 Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 Tianfei Lane, Nanjing 210004, China.
  • 3 School of Pharmacy, Nanjing Medical University, 211166 Nanjing, China.
  • 4 Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.
  • 5 Center for Global Health, School of Public Health, Nanjing Medical University, 211166 Nanjing, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 211166 Nanjing, China; Jiangsu Province Engineering Research Center of Antibody Drug, Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing 211166, China. Electronic address: jchen@njmu.edu.cn.
PMID: 33965491 DOI: 10.1016/j.ijbiomac.2021.05.031
Abstract

Burn injury has posed devastating burdens on the public health due to its inevitable damage to the skin structure resulting in the increased risk of Infection. Therefore, it is highly demanding to develop efficacious Antibacterial wound-healing dressing. Despite the favourable wound-healing activities, the curative efficacy of phytochemical compounds of quercetin (Qe) and its derivatives is limited by their poor water solubility. Here, we have fabricated a novel electrospun nanofiber membrane (ENM) consisting of polycaprolactone (PCL), chitosan oligosaccharides (COS), and Qe/Rutin (Ru) as the potential bioactive dressing for wound healing. The incorporation of chitosan oligosaccharides (COSs) in the PCL scaffold at the optimized molar ratio not only contributed to the improved hydrophilicity and water absorption performance of the ENM but effectively increased the specific surface area of the formed nanofibers. In particular, the antioxidant and Antibacterial activities of the Qe/rutin-loaded nanofiber membranes were tested, which revealed that the PCL-COS-Qe membrane exhibited superior performance among all nanofiber membranes. Therefore, the developed PCL-COS-Qe/Ru nanofiber membranes hold enormous potential as healthcare products, such as wound dressings for burn injuries.

Keywords

Electrospinning; Nanofiber; Quercetin; Rutin; Wound dressing.

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