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  3. Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling

Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling

  • Biochem Biophys Res Commun. 2021 Dec 10:582:64-71. doi: 10.1016/j.bbrc.2021.10.033.
Weizhou Wang 1,  Yanghao Wang 1,  Zhihong Tang 2,  Yongcheng Chen 1,  Zhui Liu 1,  Hao Duan 3,  Zongyu Zhong 3,  Fei He 4
Affiliations

Affiliations

  • 1 Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China; Kunming Medical University, Yunnan, China.
  • 2 Department of orthopaedics, People's Hospital of Guang'an City, Sichuan, China.
  • 3 Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
  • 4 Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China; Yunnan Province Stem Cell Technology Application Research Center, Yunnan, China; Yunnan Provincial Clinical Medical Center for Bone and Joint Diseases, Yunnan, China. Electronic address: drhefei@126.com.
PMID: 34689107 DOI: 10.1016/j.bbrc.2021.10.033
Abstract

Mesenchymal stem cells (MSCs) can promote osteogenesis and are a promising therapy for postmenopausal osteoporosis. However, the relationship between improved intraosseous microcirculation and increased bone mass induced by MSCs in postmenopausal osteoporosis remains unclear. After the primary MSCs were characterized, they were transplanted into ovariectomized mice. MSCs transplantation enhanced the trabecular number, trabecular bone volume/total volume, and trabecular bone mineral density in ovariectomized mice. To determine the role of MSCs in vascular repair, mice were subjected to femoral artery ligation. Through laser speckle flowmetry, vascular perfusion and femoral trabecular bone and cortical bone analyses, we determined the effects of MSCs in promoting intraosseous angiogenesis and preventing osteoporosis in mice. MSCs effectively prevented postmenopausal osteoporosis development, which is associated with the involvement of MSCs in reestablishment of microcirculation within the skeleton.

Keywords

Bone marrow mesenchymal stem cell; Bone mass recovery; Cellular therapy; Postmenopausal osteoporosis; Revascularization.

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