2. Academic Validation
  3. JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis

JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis

  • Int Immunopharmacol. 2022 Sep;110:109000. doi: 10.1016/j.intimp.2022.109000.
Xue-Yuan Leng 1,  Jia Yang 2,  Heng Fan 2,  Qian-Yun Chen 3,  Bing-Jie Cheng 4,  Hong-Xia He 5,  Fei Gao 2,  Feng Zhu 2,  Ting Yu 2,  Yu-Jin Liu 2
Affiliations

Affiliations

  • 1 Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China; Department of Endocrinology, The Third People's Hospital of Hubei Province, Wuhan, Hubei 430030, PR China.
  • 2 Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China.
  • 3 Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: 511958685@qq.com.
  • 4 Department of Endocrinology, The Third People's Hospital of Hubei Province, Wuhan, Hubei 430030, PR China.
  • 5 State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, PR China.
PMID: 35777266 DOI: 10.1016/j.intimp.2022.109000
Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized by chronic inflammation and ulceration of the colonic mucosa, frequent relapse, and cancerization that is difficult to cure. In recent years, the incidence of UC has increased. However, its etiology and pathogenesis are still not completely clear. In this study, dextran sodium sulfate (DSS) was used to induce the model, and GSK-J1 and dexamethasone were administered to the mice. A variety of Molecular Biology and immunological techniques, such as immunofluorescence, PCR and chromatin immunoprecipitation (ChIP), were used to examine JMJD3/H3K27me3-mediated regulation of Th17/Treg cell differentiation in UC by targeting histone modification. This study will provide an important theoretical basis for understanding the pathogenesis and potential therapeutic targets of UC.

Keywords

Epigenetic modification; H3K27me3; Inflammatory bowel disease; JMJD3; Th17 cells; Treg cells; Ulcerative colitis.

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