2. Academic Validation
  3. Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro

Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro

  • Sci Rep. 2023 Apr 8;13(1):5775. doi: 10.1038/s41598-023-32934-5.
Peipei Wang # 1 2,  Ying Zhu # 1,  Xinru Jia # 3,  Xiangchang Ying 3,  Leitao Sun 4 5,  Shanming Ruan 6
Affiliations

Affiliations

  • 1 Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
  • 2 Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
  • 3 The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
  • 4 Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China. sunnylt@zcmu.edu.cn.
  • 5 Academy of Chinese Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China. sunnylt@zcmu.edu.cn.
  • 6 Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China. shanmingruan@zcmu.edu.cn.
  • # Contributed equally.
PMID: 37031243 DOI: 10.1038/s41598-023-32934-5
Abstract

This study explored the promoting effect of oxidative stress-induced growth inhibitor family member 2(OSGIN2) on gastric Cancer (GC) through public databases and in vitro experiments. The potential relationship between OSGIN2 expression, prognosis, functional enrichment of associated differential genes, immune infiltration, and mutational information in gastric Cancer were comprehensively investigated using bioinformatics analysis. OSGIN2 was knocked down using small interfering RNA (siRNA) transfection for subsequent cell function testing. The results showed that gastric carcinoma cells and tissues contained high levels of OSGIN2, which was associated with a poor prognosis for GC patients. It was important in the cell cycle, Autophagy, etc., and was related to a variety of tumor-related signal pathways. Knockdown of OSGIN2 inhibited tumor cell proliferation and contributed to cell cycle arrest. It was also correlated with tumor immune infiltrating cells (TILs), affecting antitumor immune function. Our analysis highlights that OSING2, as a new biomarker, has diagnostic and prognostic value in gastric Cancer and is a potentially effective target in GC treatment.

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