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  3. Two new pregnane glycosides from the root of Cynanchum auriculatum

Two new pregnane glycosides from the root of Cynanchum auriculatum

  • J Asian Nat Prod Res. 2023 May 13;1-7. doi: 10.1080/10286020.2023.2211550.
Bo Hu 1,  Cai-Shi Zhang 1,  Ya-Lin Hu 1,  Huai-Yu Cheng 1,  Ting Liu 1,  Yin Liu 1,  Tian-Qi Xu 1,  Qing Shu 1,  Guang-Xiong Zhou 1
Affiliations

Affiliation

  • 1 Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
PMID: 37178131 DOI: 10.1080/10286020.2023.2211550
Abstract

Two new pregnane glycosides (1 and 2), together with four known ones (3- 6), were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Asclepiadaceae). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be metaplexigenin 3-O-β-D-cymaropyranosyl- (1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (1), metaplexigenin 3-O-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (2). All the isolated compounds (1-6) were tested for their in vitro inhibitory activity against the growth of human colon Cancer cell lines HCT-116. Compounds 5 and 6 showed significant cytoxicities with IC50 values of 43.58 µM and 52.21 µM.

Keywords

Asclepiadaceae; Cynanchum auriculatum; cytotoxic activity; pregnane glycosides.

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