2. Academic Validation
  3. Enzymatic conversion of 7-hydroxyguanine to its nucleosides

Enzymatic conversion of 7-hydroxyguanine to its nucleosides

  • J Antibiot (Tokyo). 1986 Sep;39(9):1288-90. doi: 10.7164/antibiotics.39.1288.
M Kitahara,  K Ishii,  T Okazaki,  T Hidaka,  K Watanabe
PMID: 3781927 DOI: 10.7164/antibiotics.39.1288
Abstract

7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor activity against mouse leukemia L1210 cells. The therapeutic effect of 7-hydroxyguanine deoxyriboside is superior to those of 7-hydroxyguanine and 7-hydroxyguanine riboside.

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