2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. L 888607

L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.

For research use only. We do not sell to patients.

L 888607 Chemical Structure

L 888607 Chemical Structure

CAS No. : 860033-06-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 352 In-stock
Solution
10 mM * 1 mL in DMSO USD 352 In-stock
Solid
5 mg USD 320 In-stock
10 mg USD 520 In-stock
25 mg USD 1100 In-stock
50 mg USD 1700 In-stock
100 mg USD 2400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L 888607:

L 888607 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE L 888607

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms
DP EP FP IP TXA2/TP TXB2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite[1].

IC50 & Target[1]

DP

0.8 nM (Ki)

TP Receptor

283 nM (Ki)

FP Receptor

10018 nM (Ki)

IP Receptor

14434 nM (Ki)

In Vitro

L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM[1].
L 888607 has some affinity for the human DP receptor with a Ki value of 211 nM[1].
L 888607 displays a relatively high selectivity for CRTH2 receptor[1].
L 888607 has agonistic activity on recombinant and endogenously expressed CRTH2 receptor with an EC50 value of 0.4 nM[1].
L 888607(100 nM, 20 min) stimulates eosinophil chemotaxis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L 888607 Related Antibodies

Immunofluorescence[1]

Cell Line: human eosinophils
Concentration: 100 nM
Incubation Time: 20 min
Result: Significantly stimulated the migration of eosinophils to the bottom chamber.
In Vivo

L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male (ICR)BR mice[1]
Dosage: 5 mg/kg, 20 mg/kg
Administration: i.v., 5 mg/kg, single or oral, 20 mg/kg, single
Result: Showed no obvious side effect.
Molecular Weight

375.84

Formula

C19H15ClFNO2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C[C@@H]1CCN2C1=C(SC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (266.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6607 mL 13.3035 mL 26.6071 mL
5 mM 0.5321 mL 2.6607 mL 5.3214 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.87%

SDS (251 KB)

COA (254 KB) HNMR (157 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6607 mL 13.3035 mL 26.6071 mL 66.5177 mL
5 mM 0.5321 mL 2.6607 mL 5.3214 mL 13.3035 mL
10 mM 0.2661 mL 1.3304 mL 2.6607 mL 6.6518 mL
15 mM 0.1774 mL 0.8869 mL 1.7738 mL 4.4345 mL
20 mM 0.1330 mL 0.6652 mL 1.3304 mL 3.3259 mL
25 mM 0.1064 mL 0.5321 mL 1.0643 mL 2.6607 mL
30 mM 0.0887 mL 0.4435 mL 0.8869 mL 2.2173 mL
40 mM 0.0665 mL 0.3326 mL 0.6652 mL 1.6629 mL
50 mM 0.0532 mL 0.2661 mL 0.5321 mL 1.3304 mL
60 mM 0.0443 mL 0.2217 mL 0.4435 mL 1.1086 mL
80 mM 0.0333 mL 0.1663 mL 0.3326 mL 0.8315 mL
100 mM 0.0266 mL 0.1330 mL 0.2661 mL 0.6652 mL
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L 888607 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L 888607860033-06-3L888607L-888607Prostaglandin Receptorthe chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2)oralCRTH2 receptorphysiologicalmetaboliteInhibitorinhibitorinhibit

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