2. Academic Validation
  3. Preparation and characterization of astaxanthin-loaded liposomes by phytosterol oleate instead of cholesterol

Preparation and characterization of astaxanthin-loaded liposomes by phytosterol oleate instead of cholesterol

  • Food Chem. 2025 Jan 1:462:141008. doi: 10.1016/j.foodchem.2024.141008.
Chen Zhong 1,  Tianhong Liu 1,  Jing Diao 1,  Xueting Li 2,  Mei Liu 3,  Ying Wang 4
Affiliations

Affiliations

  • 1 Marine Science Research Institute of Shandong Province, Qingdao 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao 266104, China.
  • 2 Haide College, Ocean University of China, Qingdao 266003, China.
  • 3 Marine Science Research Institute of Shandong Province, Qingdao 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao 266104, China. Electronic address: mliu_msrisd@126.com.
  • 4 Marine Science Research Institute of Shandong Province, Qingdao 266104, China; Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application, Qingdao 266104, China. Electronic address: food_rc@sina.com.
PMID: 39217746 DOI: 10.1016/j.foodchem.2024.141008
Abstract

Hydrophobic bioactive compounds like astaxanthin (AST) exhibit poor water solubility and low bioavailability. Liposomes, which serve as nanocarriers, are known for their excellent biocompatibility and minimal immunogenicity. Traditionally, liposomes have been primarily constructed using Phospholipids and Cholesterol. However, the intake of Cholesterol may pose a risk to human health. Phytosterol ester was reported to reduce level of Cholesterol and improve properties of liposomes. In this study, phytosterol oleate was used to prepare liposomes instead of Cholesterol to deliver AST (AST-P-Lip). The size range of AST-P-Lip was 100-220 nm, and the morphology was complete and uniform. In vitro studies showed that AST-P-Lip significantly enhanced the antioxidant activity and oral bioavailability of AST. During simulated digestion, AST-P-Lip protected AST from damage by gastric and intestinal digestive fluid. Additionally, AST-P-Lip had a good storage stability and safety. These results provide references for the preparation of novel liposomes and the delivery of bioactive compounds.

Keywords

Astaxanthin; Liposomes; Oral bioavailability; Phytosterol ester.

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