2. Academic Validation
  3. Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases

Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases

  • Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0077524. doi: 10.1128/aac.00775-24.
Christophe Le Terrier 1 2,  Patrik Mlynarcik 1 3,  Mustafa Sadek 1 4,  Patrice Nordmann 1 5,  Laurent Poirel 1 5
Affiliations

Affiliations

  • 1 Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
  • 2 Division of Intensive Care Unit, University Hospitals of Geneva, Geneva, Switzerland.
  • 3 Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.
  • 4 Department of Food Hygiene and Control, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
  • 5 Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland.
PMID: 39365068 DOI: 10.1128/aac.00775-24
Abstract

The relative inhibitory activities of diazabicyclooctanes (avibactam, relebactam, zidebactam, nacubactam, durlobactam), boronic acid derivatives (vaborbactam, taniborbactam, xeruborbactam), and penicillin-based sulfone derivative enmetazobactam were evaluated against several intrinsic and acquired class C β-lactamases. By contrast to vaborbactam and enmetazobactam, taniborbactam, xeruborbactam, and all diazabicyclooctanes demonstrated effective activities against most AmpC Enzymes. Notably, durlobactam exhibited the most pronounced inhibitory effect. Interstingly, the chromosomal AmpC of Acinetobacter baumannii was the least sensitive Enzyme to the newly developed β-lactamase inhibitors.

Keywords

AmpC; avibactam; class C; durlobactam; enmetazobactam; nacubactam; relebactam; taniborbactam; vaborbactam; xeruborbactam; zidebactam; β-lactamase.

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