2. Anti-infection
  3. Bacterial
  4. Xeruborbactam disodium

Xeruborbactam disodium  (Synonyms: QPX7728 disodium)

Cat. No.: HY-136072 Purity: 99.87%
COA Handling Instructions

Molarity Calculator

Xeruborbactam (QPX7728) disodium is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range.

For research use only. We do not sell to patients.

Xeruborbactam disodium Chemical Structure

Xeruborbactam disodium Chemical Structure

CAS No. : 2170848-99-2

Size Price Stock Quantity
1 mg USD 750 In-stock
5 mg USD 1650 In-stock
10 mg USD 2800 In-stock
25 mg USD 4800 In-stock
50 mg USD 7500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Xeruborbactam disodium:

Xeruborbactam disodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Xeruborbactam disodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Xeruborbactam (QPX7728) disodium is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range[1].

In Vitro

Xeruborbactam disodium is a potent inhibitor of Class D carbapenemases from A. baumannii[1].
Xeruborbactam disodium is minimally affected by the activity of major MDR efflux pumps from P. aeruginosa, representing a significant improvement over the earlier generation boronate beta-lactamase inhibitor (BLI) vaborbactam[1].
The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate Xeruborbactam disodium is a useful inhibitor for use with multiple beta-lactam antibiotics[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xeruborbactam disodium Related Antibodies
Clinical Trial
Molecular Weight

283.96

Formula

C10H8BFNa2O5
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O[B-](O1)(O)[C@@H]2C[C@@H]2C3=C1C(C(O[Na])=O)=C(C=C3)F.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (352.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 76.67 mg/mL (270.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5216 mL 17.6081 mL 35.2162 mL
5 mM 0.7043 mL 3.5216 mL 7.0432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 66.67 mg/mL (234.79 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

COA (256 KB) HNMR (242 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.5216 mL 17.6081 mL 35.2162 mL 88.0406 mL
5 mM 0.7043 mL 3.5216 mL 7.0432 mL 17.6081 mL
10 mM 0.3522 mL 1.7608 mL 3.5216 mL 8.8041 mL
15 mM 0.2348 mL 1.1739 mL 2.3477 mL 5.8694 mL
20 mM 0.1761 mL 0.8804 mL 1.7608 mL 4.4020 mL
25 mM 0.1409 mL 0.7043 mL 1.4086 mL 3.5216 mL
30 mM 0.1174 mL 0.5869 mL 1.1739 mL 2.9347 mL
40 mM 0.0880 mL 0.4402 mL 0.8804 mL 2.2010 mL
50 mM 0.0704 mL 0.3522 mL 0.7043 mL 1.7608 mL
60 mM 0.0587 mL 0.2935 mL 0.5869 mL 1.4673 mL
80 mM 0.0440 mL 0.2201 mL 0.4402 mL 1.1005 mL
100 mM 0.0352 mL 0.1761 mL 0.3522 mL 0.8804 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Xeruborbactam disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xeruborbactam disodium2170848-99-2QPX7728 disodiumBacterialMDR effluxEnterobacteriaceaePseudomonas aeruginosaAcinetobacter baumanniiantibioticserinemetalloInhibitorinhibitorinhibit

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