2. Academic Validation
  3. Construction of BSA-ZnO&Quercetin based multifunctional bionic self-assembly system and their antibacterial mechanism study

Construction of BSA-ZnO&Quercetin based multifunctional bionic self-assembly system and their antibacterial mechanism study

  • Colloids Surf B Biointerfaces. 2024 Oct 5:245:114288. doi: 10.1016/j.colsurfb.2024.114288.
Shuxian Hou 1,  Ye Hong 2,  Jihua Shang 3,  Yimei Wang 1,  Xuechao Shi 1,  Xinxin Liu 1,  Guoqiang Yang 1,  Yuxuan Wang 1,  Fei Ge 1,  Yao Xiao 1,  Chaldi Kaoutar 1,  Yuan Wu 4,  Jun Wang 5
Affiliations

Affiliations

  • 1 School of Biological and food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China.
  • 2 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210006, China.
  • 3 Department of Modern Analysis and Testing, Anhui Polytechnic University, Wuhu, Anhui 241000, China.
  • 4 Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.
  • 5 School of Biological and food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address: jwang@mail.ahpu.edu.cn.
PMID: 39395214 DOI: 10.1016/j.colsurfb.2024.114288
Abstract

The misuse of Antibiotics has led to the growing problem of multidrug-resistant (MDR) bacteria, and there is still a lack of effective Antibacterial agents that can replace Antibiotics. Therefore, the design and development of multifunctional nanomaterials with long-term inhibitory effects on drug-resistant bacteria are extremely challenging. In this study, a multifunctional biomimetic self-assembly system, BSA-ZnO&Quercetin, based on bovine serum albumin (BSA), ZnO, and quercetin, was established using a simple and controllable method. The prepared self-assembly system has high stability and biocompatibility, and could fully combine the performance advantages of each component. BSA-ZnO&Quercetin showed excellent broad-spectrum Antibacterial activity without inducing Bacterial resistance. The related Antibacterial mechanism of BSA-ZnO&Quercetin primarily involves biofilm inhibition and destruction, and inducing the production of Reactive Oxygen Species, resulting in the death of the bacteria. The biomimetic self-assembly system BSA-ZnO&Quercetin constructed in this research is expected to replace Antibiotics for Antibacterial application.

Keywords

Antibacterial mechanism; Bionic self-assembly; Quercetin; Zinc oxide.

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