1. Academic Validation
  2. A Novel UBM/SIS Composite Biological Scaffold for 2-Year Abdominal Defect Repairing and Strength Recovery in Canine Model

A Novel UBM/SIS Composite Biological Scaffold for 2-Year Abdominal Defect Repairing and Strength Recovery in Canine Model

  • Adv Biol (Weinh). 2025 Jan;9(1):e2400131. doi: 10.1002/adbi.202400131.
Weidong Zhong 1 2 Jinshui Chen 3 Qifeng Xie 1 Wenyue Cheng 1 Meibiao Zhao 1 Yang Sun 1 Jing Dai 1 Jian Zhang 1
Affiliations

Affiliations

  • 1 Department of Colorectal Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
  • 2 Department of Gastrointestinal Surgery, Jiangyin People's Hospital Affiliated to Nantong University, Jiangyin, 214400, China.
  • 3 Department of General Surgery, The 991st Hospital of Joint Logistic Support Force of People's Liberation Army, Xiangyang, Hubei, 441003, China.
Abstract

Biological scaffolds are widely utilized in hernia treatment due to their exceptional pro-regenerative properties, which mitigate scar formation. However, serious complications occurred, caused by inflammatory response, premature degradation, and mechanical failure. Consequently, improvements of the biological scaffold are necessary to mitigate these risks. In this study, a novel biological scaffold integrating basement membrane-containing urinary bladder matrix (UBM) and small intestinal submucosa (SIS) is developed, and its safety and effectiveness are assessed in comparison to a commercial SIS (c-SIS) scaffold. The introduction of UBM as top surface layers significantly promotes cell adhesion, facilitating rapid formation of isolated regeneration zone. Proteomic analysis has demonstrated a more efficient decellularization of the UBM/SIS scaffold, which subsequently mitigates inflammation in murine models, and promotes the polarization of macrophages toward the pro-healing M2 phenotype in a rat model of abdominal wall muscle defect. Furthermore, a two-year repair trial is conducted on a full-thickness abdominal wall muscle defect in canine model and confirmed that the UBM/SIS scaffold exhibits reduced seroma occurrences and enhanced tissue repair performances. Overall, the efficacy of this novel biological scaffold suggests its potential to minimize hernia recurrence in clinical practice and mitigate patient suffering from severe inflammatory responses.

Keywords

abdominal wall repair; biological scaffolds; canine model; small intestinal submucosa; urinary bladder matrix.

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