2. Academic Validation
  3. Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy

Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy

  • Bioact Mater. 2024 Dec 10:46:82-96. doi: 10.1016/j.bioactmat.2024.12.001.
Fei Wang 1 2,  Lanya Li 1 2,  Junyao Deng 1 3,  Jiacong Ai 1 3,  Shushan Mo 1,  Dandan Ding 1 2,  Yingxian Xiao 1 3,  Shiqi Hu 4,  Dashuai Zhu 4,  Qishan Li 1 2,  Yan Zeng 1,  Zhitong Chen 5,  Ke Cheng 4,  Zhenhua Li 1 2
Affiliations

Affiliations

  • 1 The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), 523059, Dongguan, China.
  • 2 Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, 510515, Guangzhou, China.
  • 3 The First School of Clinical Medicine, Southern Medical University, 510515, Guangzhou, China.
  • 4 Department of Biomedical Engineering, Columbia University, 10032, New York, NY, USA.
  • 5 Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, China.
PMID: 39737211 DOI: 10.1016/j.bioactmat.2024.12.001
Abstract

Plant-derived extracellular vesicles (PEVs) have been regarded as a superior source for nanomedicine and drug delivery systems. Nevertheless, their clinical translation is hindered by the lack of clarity and even contradiction in their biomedical applications. Herein, we conducted a comprehensive compositional analysis of four commonly used PEVs to fully understand their functional lipid contents and assess their potential therapeutic applications. The lipidomic analysis revealed the presence of cytotoxic gingerols and shogaols in ginger-derived EVs (GEVs). Subsequent in vitro and in vivo investigations substantiated the remarkable tumor cell inhibitory and tumor growth suppression efficacy of GEVs. The transcriptomic analysis indicated that GEVs regulate the cell cycle and p53 signaling pathways, thereby inducing Cancer cell Apoptosis. The supplementary proteomic analysis suggested the potential protein markers in PEV research. These findings highlight the value of multi-omics analyses in elucidating the potential therapeutic effects of PEVs and in advancing the development of PEV-based therapies.

Keywords

Ginger; Lipidomic analysis; Plant-derived extracellular vesicles; Protein markers; anti-cancer therapy.

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