[Action of pristinamycin on Chlamydia]

In vitro study on C. psittaci and C. trachomatis demonstrates that pristinamycin is active in a very small dose. With 5 g/l, inclusions are rare. To study pristinamycin activity in vivo, we used mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg pristinamycin respectively. The Antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage. Due to its action on Gonococcus, it would be of interest to study pristinamycin in patients with sexually transmitted disease.