2. Anti-infection
  3. Bacterial Antibiotic
  4. Pristinamycin

Pristinamycin  (Synonyms: Pristinamycine)

Cat. No.: HY-A0279 Purity: 99.63%
SDS COA Handling Instructions

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Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF).

For research use only. We do not sell to patients.

Pristinamycin Chemical Structure

Pristinamycin Chemical Structure

CAS No. : 270076-60-3

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5 mg USD 250 In-stock
10 mg USD 400 In-stock
25 mg USD 850 In-stock
50 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pristinamycin:

Pristinamycin Related Antibodies

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Description

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF)[1].

In Vitro

In-vitro studies show pristinamycin to inhibit Staphylococci and Streptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pristinamycin Related Antibodies
In Vivo

To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

1392.55

Formula

C73H89N11O17
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N[C@@H]1C(N[C@H](CC)C(N2[C@](CCC2)([H])C(N(C)[C@@H](CC3=CC=C(N(C)C)C=C3)C(N4[C@](CC(CC4)=O)([H])C(N[C@@H](C5=CC=CC=C5)C(O[C@@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O.O=C7N8C(C(O[C@@H]([C@@H](/C=C/C(NC/C=C/C(C)=C/[C@H](CC(CC9=NC7=CO9)=O)O)=O)C)C(C)C)=O)=CCC8
Structure Classification
Initial Source

streptogramin
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (71.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7181 mL 3.5905 mL 7.1811 mL
5 mM 0.1436 mL 0.7181 mL 1.4362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.63%

SDS (251 KB)

COA (258 KB) LCMS (109 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7181 mL 3.5905 mL 7.1811 mL 17.9527 mL
5 mM 0.1436 mL 0.7181 mL 1.4362 mL 3.5905 mL
10 mM 0.0718 mL 0.3591 mL 0.7181 mL 1.7953 mL
15 mM 0.0479 mL 0.2394 mL 0.4787 mL 1.1968 mL
20 mM 0.0359 mL 0.1795 mL 0.3591 mL 0.8976 mL
25 mM 0.0287 mL 0.1436 mL 0.2872 mL 0.7181 mL
30 mM 0.0239 mL 0.1197 mL 0.2394 mL 0.5984 mL
40 mM 0.0180 mL 0.0898 mL 0.1795 mL 0.4488 mL
50 mM 0.0144 mL 0.0718 mL 0.1436 mL 0.3591 mL
60 mM 0.0120 mL 0.0598 mL 0.1197 mL 0.2992 mL
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Pristinamycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pristinamycin270076-60-3PristinamycineBacterialAntibioticoralpathogensresistantGram-positivebacteriaInhibitorinhibitorinhibit

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