MDNI-caged-L-glutamate  (Synonyms: MDNI-glu)

MDNI-caged-L-glutamate (MDNI-glu) is a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate. MDNI-caged-L-glutamate makes more efficient use of incident light^[1].

368.30

C₁₄H₁₆N₄O₈

864085-92-7

O=C(O)[C@@H](N)CCC(N1CCC2=C1C([N+]([O-])=O)=CC([N+]([O-])=O)=C2OC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Olesya D Fedoryak,et al. Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem Commun (Camb). 2005 Aug 7;(29):3664-6.  [Content Brief]

  [2]. Papageorgiou G, Ogden D, Kelly G, Corrie JE. Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem Photobiol Sci. 2005;4(11):887-896.  [Content Brief]

  [3]. Morgante P, Guruge C, Ouedraogo YP, Nesnas N, Peverati R. Competition between cyclization and unusual Norrish type I and type II nitro-acyl migration pathways in the photouncaging of 1-acyl-7-nitroindoline revealed by computations. Sci Rep. 2021;11(1):1396.  [Content Brief]