2. Metabolic Enzyme/Protease GPCR/G Protein
  3. ATP Citrate Lyase Free Fatty Acid Receptor
  4. MEDICA16

MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120.

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MEDICA16 Chemical Structure

MEDICA16 Chemical Structure

CAS No. : 87272-20-6

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10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].

Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
0.08 mM
Compound: 4d
Inhibition of lipid synthesis, by incorporation of 3H20 into 3-beta-hydroxysterols in cultured rat hepatocytes
Inhibition of lipid synthesis, by incorporation of 3H20 into 3-beta-hydroxysterols in cultured rat hepatocytes
[PMID: 2788743]
Hepatocyte IC50
0.08 mM
Compound: 4d
Inhibition of lipid synthesis, by incorporation of 3H20 into saponified fatty acids in cultured rat hepatocytes
Inhibition of lipid synthesis, by incorporation of 3H20 into saponified fatty acids in cultured rat hepatocytes
[PMID: 2788743]
Molecular Weight

342.51

Formula

C20H38O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CC(C)(C)CCCCCCCCCCC(C)(C)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (291.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9196 mL 14.5981 mL 29.1962 mL
5 mM 0.5839 mL 2.9196 mL 5.8392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9196 mL 14.5981 mL 29.1962 mL 72.9906 mL
5 mM 0.5839 mL 2.9196 mL 5.8392 mL 14.5981 mL
10 mM 0.2920 mL 1.4598 mL 2.9196 mL 7.2991 mL
15 mM 0.1946 mL 0.9732 mL 1.9464 mL 4.8660 mL
20 mM 0.1460 mL 0.7299 mL 1.4598 mL 3.6495 mL
25 mM 0.1168 mL 0.5839 mL 1.1678 mL 2.9196 mL
30 mM 0.0973 mL 0.4866 mL 0.9732 mL 2.4330 mL
40 mM 0.0730 mL 0.3650 mL 0.7299 mL 1.8248 mL
50 mM 0.0584 mL 0.2920 mL 0.5839 mL 1.4598 mL
60 mM 0.0487 mL 0.2433 mL 0.4866 mL 1.2165 mL
80 mM 0.0365 mL 0.1825 mL 0.3650 mL 0.9124 mL
100 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7299 mL
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MEDICA16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEDICA1687272-20-6MEDICA 16MEDICA-16ATP Citrate LyaseFree Fatty Acid ReceptorACLYFFARskeletalmuscleinsulinendogenousligandsantidiabeticantidiabetogenicInhibitorinhibitorinhibit

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