Medroxyprogesterone-d₃  (Synonyms: 17α-Hydroxy-6α-methylprogesterone-d₃; U8840-d₃)

Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

347.51

C₂₂H₂₉D₃O₃

162462-69-3

520-85-4

Solid

Off-white to gray

C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C([C@H](C3)C([2H])([2H])[2H])=CC(CC4)=O)C

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. http://en.wikipedia.org/wiki/Medroxyprogesterone