2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Melagatran

Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion.

For research use only. We do not sell to patients.

Melagatran Chemical Structure

Melagatran Chemical Structure

CAS No. : 159776-70-2

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1 mg USD 653 In-stock
5 mg USD 1520 In-stock
10 mg USD 1980 In-stock
25 mg USD 2970 In-stock
50 mg USD 3970 In-stock
100 mg USD 5550 In-stock
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Melagatran Related Antibodies

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Description

Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].

IC50 & Target

Thrombin[1]
Molecular Weight

429.51

Formula

C22H31N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(C(C=C1)=CC=C1CNC([C@@H]2CCN2C([C@@H](C3CCCCC3)NCC(O)=O)=O)=O)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (407.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3282 mL 11.6412 mL 23.2823 mL
5 mM 0.4656 mL 2.3282 mL 4.6565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.31%

SDS (251 KB)

COA (246 KB) HNMR (268 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3282 mL 11.6412 mL 23.2823 mL 58.2059 mL
5 mM 0.4656 mL 2.3282 mL 4.6565 mL 11.6412 mL
10 mM 0.2328 mL 1.1641 mL 2.3282 mL 5.8206 mL
15 mM 0.1552 mL 0.7761 mL 1.5522 mL 3.8804 mL
20 mM 0.1164 mL 0.5821 mL 1.1641 mL 2.9103 mL
25 mM 0.0931 mL 0.4656 mL 0.9313 mL 2.3282 mL
30 mM 0.0776 mL 0.3880 mL 0.7761 mL 1.9402 mL
40 mM 0.0582 mL 0.2910 mL 0.5821 mL 1.4551 mL
50 mM 0.0466 mL 0.2328 mL 0.4656 mL 1.1641 mL
60 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9701 mL
80 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7276 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.5821 mL
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Melagatran Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melagatran159776-70-2ThrombinInhibitorinhibitorinhibit

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