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  4. Melarsoprol

Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African trypanosomiasis. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats.

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Melarsoprol Chemical Structure

Melarsoprol Chemical Structure

CAS No. : 494-79-1

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Melarsoprol Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African trypanosomiasis. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats[1].

Molecular Weight

398.34

Formula

C12H15AsN6OS2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC1S[As](SC1)C2=CC=C(C=C2)NC3=NC(N)=NC(N)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 36 mg/mL (90.38 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5104 mL 12.5521 mL 25.1042 mL
5 mM 0.5021 mL 2.5104 mL 5.0208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5104 mL 12.5521 mL 25.1042 mL 62.7605 mL
5 mM 0.5021 mL 2.5104 mL 5.0208 mL 12.5521 mL
10 mM 0.2510 mL 1.2552 mL 2.5104 mL 6.2760 mL
15 mM 0.1674 mL 0.8368 mL 1.6736 mL 4.1840 mL
20 mM 0.1255 mL 0.6276 mL 1.2552 mL 3.1380 mL
25 mM 0.1004 mL 0.5021 mL 1.0042 mL 2.5104 mL
30 mM 0.0837 mL 0.4184 mL 0.8368 mL 2.0920 mL
40 mM 0.0628 mL 0.3138 mL 0.6276 mL 1.5690 mL
50 mM 0.0502 mL 0.2510 mL 0.5021 mL 1.2552 mL
60 mM 0.0418 mL 0.2092 mL 0.4184 mL 1.0460 mL
80 mM 0.0314 mL 0.1569 mL 0.3138 mL 0.7845 mL
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Melarsoprol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melarsoprol494-79-1ParasiteMelaminophenylarsinetrivalent organic arsenicalAfrican trypanosomiasisleukemia cellplasma cellmyelomaGSHInhibitorinhibitorinhibit

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